Azetidine → 4-(Azetidine-1-carbonyl)-2-methyl-2H-pyrazole-3-carboxylic acid [2-(3-methoxy-pyrrolidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-amide

HRID 1844486Notes

Reaction equation

HRID 1844486 reaction equation
[NH:1]1[CH2:4][CH2:3][CH2:2]1.[CH3:5][O:6][CH:7]1[CH2:11][CH2:10][N:9]([C:12]2[N:32]=[C:15]3[CH:16]=[CH:17][C:18]([NH:20][C:21]([C:23]4[N:27]([CH3:28])[N:26]=[CH:25][C:24]=4[C:29](O)=[O:30])=[O:22])=[CH:19][N:14]3[N:13]=2)[CH2:8]1>>[CH3:5][O:6][CH:7]1[CH2:11][CH2:10][N:9]([C:12]2[N:32]=[C:15]3[CH:16]=[CH:17][C:18]([NH:20][C:21]([C:23]4[N:27]([CH3:28])[N:26]=[CH:25][C:24]=4[C:29]([N:1]4[CH2:4][CH2:3][CH2:2]4)=[O:30])=[O:22])=[CH:19][N:14]3[N:13]=2)[CH2:8]1

Participants

3

Reactant 2

HCID 10422AzetidineHCID 894643825-[2-(3-Methoxy-pyrrolidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl]-1-methyl-1H-pyrazole-4-carboxylic acid

Product 1

HCID 715350484-(Azetidine-1-carbonyl)-2-methyl-2H-pyrazole-3-carboxylic acid [2-(3-methoxy-pyrrolidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-amide

Procedure

Using azetidine and 5-[2-(3-Methoxy-pyrrolidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl]-1-methyl-1H-pyrazole-4-carboxylic acid, the title compound was prepared in the same manner as described for example 2. Off white solid (57 mg, 43%). MS: m/z=425 (M+H+).

Sources & evidence

ORD record
ord-27ea433f250347828b32f74450e1282a
Source dataset
uspto-grants-2015_02
Patent number
US08946427B2

Reaction notes

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