HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → 2-(1H-Pyrazol-3-Yl)Pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | (Z)-3-(dimethylamino)-1-(pyridin-2-yl)prop-2-en-1-one | HCID 86719369 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-(1H-Pyrazol-3-Yl)Pyridine | HCID 2797657 | 97.3% |
Reaction Steps
Compound 16a (1 g, 6.2 mmol) obtained from the aforesaid process and hydrazine hydrate (2 mL) were dissolved in ethanol (3.3 mL), and reacted at 60° C. for 0.5 hour. Then, the mixture was cooled to room temperature, and then the solvent was removed in vacuum to afford the product 17a (874.7 mg) as a faint yellow solid, with a yield of 97.3%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946436B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-8efd030e96c24c988ac782956cba7793 |
| Source note | uspto-grants-2015_02 |