HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Methyl 4-formyl-2-hydroxybenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Reactant | Methyl 4-formyl-2-methoxybenzoate | HCID 18510332 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methyl 4-formyl-2-hydroxybenzoate | HCID 21626741 | 92% |
Reaction Steps
A mixture of product from Step 2 (2.6 g, 13.4 mmol) and AlCl3 (3.6 g, 26.8 mmol) in anhydrous DCM (50 mL) was refluxed for 3 minutes. The resulting mixture was cooled and poured into water (100 mL), followed by a standard aqueous/DCM workup to give Intermediate 5 (2.2 g, yield 92%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946434B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-54f2fd5a5b094992b391403d4357bf9f |
| Source note | uspto-grants-2015_02 |