HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aluminum(III) Chloride → Methyl 2-fluoro-4-formyl-6-hydroxybenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Reactant | Methyl 4-formyl-2-hydroxybenzoate | HCID 21626741 | — |
| Reactant | Methyl 2-fluoro-4-formyl-6-methoxybenzoate | HCID 86681499 | — |
| Product | Methyl 2-fluoro-4-formyl-6-hydroxybenzoate | HCID 86669343 | 97.1% |
Reaction Steps
Followed procedure described in Intermediate 5, step 3 starting with methyl 2-fluoro-4-formyl-6-methoxybenzoate (280 mg, 1.3 mmol) and AlCl3 (350 mg, 2.6 mmol) where reaction was complete after refluxing 10 min. Isolated 250 mg of Intermediate 7, yield 96%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946434B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-3dc04010bd2b466aaca8cfac45aa3a5a |
| Source note | uspto-grants-2015_02 |