Dimethylformamide → HCID 86720682, compound

Participants

Reaction Steps

DMF (0.7 ml) and DMF acetal (0.22 g, 0.25 ml, 1.88 mmol) were added subsequently to a solution of N-methoxy-5-(6-methoxy-4′-sulfamoyl-[1,1′-biphenyl]-3-yl)-N,4-dimethylthiazole-2-carboxamide (8c, 0.70 g, 1.56 mmol) in ethyl acetate (12 ml) at room temperature. The reaction mixture was then stirred at room temperature for 15 hr under nitrogen atmosphere. The progress of the reaction was monitored by TLC. The solid obtained was filtered and washed with ether (10 ml) to obtain the title compound 8d (0.60 g, 76.33%).

Provenance & Evidence