Sodium Hydroxide → HCID 71203601, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 5-(6-methoxy-4′-sulfamoyl-[1,1′-biphenyl]-3-yl)-1,4-dimethyl-1H-pyrrole-2-carboxylate (step-2, 0.77 g, 1.85 mmol) was suspended in ethanol (15 ml), to this was then added aqueous solution of NaOH (0.37 g. 9.29 mmol in 5 ml water) at 0° C. The reaction mixture was stirred at 25° C. for 15 hours. The progress of the reaction was monitored by TLC. The reaction mixture was concentrated under reduced pressure. The residue obtained after concentration was then dissolved in water (10 ml) and dilute hydrochloric acid was added to the mixture so obtained to bring the pH of the mixture to between 6 and 7. The mixture was then extracted with ethyl acetate (2×50 ml). The separated combined organic layer was then dried over anhydrous sodium sulfate. The solvent was evaporated from the dried organic layer under reduced pressure to obtain the title compound 10c (0.71 g, 95.9%).

Provenance & Evidence