Dimethylformamide → HCID 86720685, compound

Participants

Reaction Steps

DMF (0.65 ml) and DMF acetal (0.19 g, 0.21 ml, 1.61 mmol) were added to a solution of N-methoxy-5-(6-methoxy-4′-sulfamoyl-[1,1′-biphenyl]-3-yl)-N,1,4-trimethyl-1H-pyrrole-2-carboxamide (10d, 0.65 g, 1.46 mmol) in ethyl acetate (13 ml) under stirring at room temperature. The mixture was stirred at room temperature for 15 hr under nitrogen atmosphere. The progress of the reaction was monitored by TLC. The reaction mixture was diluted with ethyl acetate (50 ml) and the mixture so obtained was washed with water (2×20 ml). The organic layer separated was dried over Na2SO4 and concentrated to obtain a crude product. The crude product was purified by flash column chromatography using 4% methanol in DCM as an eluent to obtain the title compound 10e (0.62 g, 84.9%).

Provenance & Evidence