HCID 86720685, compound → HCID 71187175, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl magnesium bromide (0.53 g, 3.96 ml, 3.98 mmol) was added drop wise to a solution of 5-(4′-(N-((dimethylamino)methylene)sulfamoyl)-6-methoxy-[1,1′-biphenyl]-3-yl)-N-methoxy-N,1,4-trimethyl-1H-pyrrole-2-carboxamide (Step 5, 0.4 g, 0.80 mmol) in anhydrous THF (10 ml) under stirring at 25° C. The reaction mixture was heated at 70-75° C. for 1 hour. The progress of the reaction was monitored by TLC. The reaction mixture was then cooled to 0° C. and was quenched by addition of saturated solution of ammonium chloride (10 ml). The resulting mixture was extracted with ethyl acetate (3×30 ml). The combined organic layer was dried over anhydrous Na2SO4. The solvent was evaporated from the dried organic layer under reduced pressure to obtain a crude product, which was then purified by column chromatography using mixture of ethyl acetate and hexane as an eluent to obtain the title compound 10 (0.04 g, 12.12%).

Provenance & Evidence