反应详情

A solution of (Z)-tert-butyl 2-chloro-5-(2-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl)-4H-thieno[3,2-b]pyrrole-4-carboxylate (10 mg) in 2 mL of 88% aqueous formic acid solution was sonicated in an ultrasonic bath for 1 h and then concentrated in vacuo. The residue was purified by Combiflash on a silica gel column eluted with a gradient up to 70% EtOAc/hexanes to give 5 mg of the title compound as a dark solid.

1. concentrationconcentrated in vacuo
2. customThe residue was purified by Combiflash on a silica gel column
3. washeluted with a gradient up to 70% EtOAc/hexanes