5-Bromo-2-fluoropyridine → 3-(6-Fluoropyridine-3-yl)-5-(4-(4-methoxyphenyl)piperazin-1-yl)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-3-ol

HRID 184460Notes

Reaction equation

HRID 184460 reaction equation
[Br:30][c:31]1[cH:32][cH:33][c:34]([F:37])[n:35][cH:36]1.[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([N:9]2[CH2:10][CH2:11][N:12]([c:15]3[c:16]([CH3:29])[c:17]([CH3:28])[c:18]4[c:19]([c:26]3[CH3:27])[C:20](=[O:25])[C:21]([CH3:23])([CH3:24])[O:22]4)[CH2:13][CH2:14]2)[cH:7][cH:8]1>>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([N:9]2[CH2:10][CH2:11][N:12]([c:15]3[c:16]([CH3:29])[c:17]([CH3:28])[c:18]4[c:19]([c:26]3[CH3:27])[C:20]([OH:25])([c:31]3[cH:32][cH:33][c:34]([F:37])[n:35][cH:36]3)[C:21]([CH3:23])([CH3:24])[O:22]4)[CH2:13][CH2:14]2)[cH:7][cH:8]1

Participants

3

Reactant 2

HCID 27831685-Bromo-2-fluoropyridineHCID 229355955-[4-(4-methoxyphenyl)piperazin-1-yl]-2,2,4,6,7-pentamethyl-1-benzofuran-3(2H)-one

Product 1

HCID 588473313-(6-Fluoropyridine-3-yl)-5-(4-(4-methoxyphenyl)piperazin-1-yl)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-3-ol

Sources & evidence

ORD record
ord-65f05c00be4247d08e026189c693b384
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

Loading…