HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1844603Generated: November 2, 2026
Sodium methanethiolate → 5-Tert-butyl-2-methoxy-1-methylsulphanylmethyl-3-nitro-benzene
https://huagongshe.com/reaction/1844603
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium methanethiolate | HCID 4378561 | — |
| Reactant | 5-Tert-butyl-2-methoxy-3-nitro-benzyl methanesulphonate | HCID 58493954 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 5-Tert-butyl-2-methoxy-1-methylsulphanylmethyl-3-nitro-benzene | HCID 58493925 | — |
Reaction Steps
At ambient temperature 1.50 g sodium thiomethoxide are added to a solution of 4.64 g 5-tert-butyl-2-methoxy-3-nitro-benzyl methanesulphonate in 50 ml of 1,4-dioxane. The solution is stirred overnight at 40° C. Then the solvent is removed and the residue is chromatographed on silica gel with cyclohexane/ethyl acetate (98:2→60:40) as eluant.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08946438B2 |
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| Source dataset | uspto-grants-2015_02 |
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| ORD ID | ord-25c56a94966044f58e93f83cffabf7cc |
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| Source note | uspto-grants-2015_02 |
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