Pyridine → HCID 67217630, compound

HRID 1844608Notes

Reaction equation

HRID 1844608 reaction equation
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[NH2:6][C:7]1[CH:12]=[C:11]([C:13]([CH3:16])([CH3:15])[CH3:14])[CH:10]=[C:9]([NH2:17])[C:8]=1[O:18][CH:19]([CH3:21])[CH3:20].N1C=CC=CC=1>ClCCl>[NH2:6][C:7]1[C:8]([O:18][CH:19]([CH3:21])[CH3:20])=[C:9]([NH:17][S:2]([CH3:1])(=[O:4])=[O:3])[CH:10]=[C:11]([C:13]([CH3:16])([CH3:14])[CH3:15])[CH:12]=1

Participants

5

Reactant 3

HCID 1049PyridineHCID 31297Methanesulfonyl chlorideHCID 67491247HCID 67491247, compound

Product 1

HCID 67217630HCID 67217630, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

At ambient temperature 0.20 ml methanesulphonic acid chloride are added dropwise to a solution of 0.48 g 1,3-diamino-5-tert-butyl-2-isopropoxy-benzene and 0.35 ml of pyridine in 5 ml dichloromethane. The solution is stirred for 2 h at ambient temperature and then evaporated down. The residue is chromatographed on silica gel with cyclohexane/ethyl acetate (90:10→40:60) as eluant.

Workup

  1. customevaporated down
  2. customThe residue is chromatographed on silica gel with cyclohexane/ethyl acetate (90:10→40:60) as eluant

Sources & evidence

ORD record
ord-72e3a42a27ef4c80a9343361661c8be1
Source dataset
uspto-grants-2015_02
Patent number
US08946438B2

Reaction notes

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