1,2-Dichloroethane → HCID 58218982, compound

Participants

Reaction Steps

Methyl 5-amino-2-hydroxybenzoate (500 mg, 2.99 mmol) was taken up in DMF (15 mL) along with (R)-α-lipoic acid (TCI, 618 mg, 2.99 mmol) and EDC (630 mg, 3.3 mmol). The resulting reaction mixture was stirred at room temperature for 18 h and then diluted with EtOAc (60 mL). The organic layer was washed with water (3×10 mL), brine, dried (Na2SO4) and concentrated under reduced pressure. Purification by chromatography (95% CH2Cl2, 5% MeOH) afforded 650 mg of (S)-methyl 5-(5-(1,2-dithiolan-3-yl)pentanamido)-2-hydroxybenzoate (61%). Mass calculated for C16H21NO4S2=355.09. found: [M+H]+=356.

Provenance & Evidence