HCID 68299242, compound → HCID 68299228, compound

HRID 1844658Notes

Reaction equation

HRID 1844658 reaction equation
[CH2:1]([O:3][C:4](=[O:14])[CH:5]=[C:6]1[CH2:11][CH2:10][N:9]([O:12][CH3:13])[CH2:8][CH2:7]1)[CH3:2]>CO.[Pd]>[CH2:1]([O:3][C:4](=[O:14])[CH2:5][CH:6]1[CH2:7][CH2:8][N:9]([O:12][CH3:13])[CH2:10][CH2:11]1)[CH3:2]

Participants

4

Reactant 1

HCID 68299242HCID 68299242, compound

Product 1

HCID 68299228HCID 68299228, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of (1-methoxy-piperidin-4-ylidene)-acetic acid ethyl ester (597 mg, 3 mmol) in 20 ml of methanol was added 10% Pd/C (100 mg). The mixture was hydrogenated for 2 h and filtered. The filtrate was concentrated under reduced pressure to give the crude product, which was directly used in the next step without further purification. Yield: 500 mg of (1-methoxy-piperidin-4-yl)-acetic acid ethyl ester as an oil.

Workup

  1. filtrationfiltered
  2. concentrationThe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-ce6daa5115d44d03825f867d80054942
Source dataset
uspto-grants-2015_02
Patent number
US08946453B2

Reaction notes

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