Aluminium lithium hydride → HCID 68299260, compound

Participants

Reaction Steps

A solution of (1-methoxy-piperidin-4-yl)-acetic acid ethyl ester (16.7 g, 83 mmol) in 50 ml of THF was added dropwise to a suspension of lithium aluminum hydride (6.3 g, 166 mmol) in 150 ml of THF at 0° C. under nitrogen. After the addition, the mixture was warmed to room temperature for 2 h. Then, the resulting mixture was poured into 500 ml of ice water and extracted with CH2Cl2 three times. The combined organic layers were dried over sodium sulfate, filtered and evaporated under reduced pressure. The residue was purified by column chromatography on silica gel. Yield: 12.0 g of 2-(1-methoxy-piperidin-4-yl)-ethanol as an oil.

Provenance & Evidence