2,4,6-Trimethylbenzeneacetyl chloride → HCID 68299237, compound

Participants

Reaction Steps

A mixture of 2-hydroxy-3-(1-methoxy-piperidin-4-yl)-propionic acid methyl ester (700 mg, 3.5 mmol) and (2,4,6-trimethyl-phenyl)-acetyl chloride (700 mg, 3.6 mmol) in 10 ml of toluene was refluxed for 6 h. Then, the reaction mixture was concentrated under vacuum to dryness and the residue was purified by column chromatography on silica gel. Yield: 520 mg of 3-(1-methoxy-piperidin-4-yl)-2-[2-(2,4,6-trimethyl-phenyl)-acetoxy]-propionic acid methyl ester (title compound P3.12) as a oil.

Provenance & Evidence