m-Chloroperbenzoic acid → HCID 68353077, compound

Participants

Reaction Steps

A solution of m-CPBA (189 mg, 1.1 mmol) in 5 ml of CH2Cl2 was added slowly to a stirred solution of carbonic acid 4-(2,5-dimethyl-phenyl)-5-oxo-2-(tetrahydro-thiopyran-4-ylmethyl)-2,5-dihydro-1H-pyrrol-3-yl ester ethyl ester (compound P1.2) (390 mg, 1.0 mmol) in 10 ml CH2Cl2 and the reaction mixture was stirred at room temperature for 1 h. Then, the resulting mixture was washed with saturated NaHCO3 (aq) and aqueous Na2S2O3, respectively. The organic layer was dried over sodium sulfate, filtered and concentrated under reduce pressure. The residue was purified by chromatography on silica gel. Yield: 100 mg of carbonic acid 4-(2,5-dimethyl-phenyl)-5-oxo-2-(1-oxo-hexahydro-1λ4-thiopyran-4-ylmethyl)-2,5-dihydro-1H-pyrrol-3-yl ester ethyl ester (compound P1.4) as a solid, mp 103-106° C.

Provenance & Evidence