Benzyl Bromide → HCID 68299250, compound

Participants

Reaction Steps

A solution of 3-(2,5-dimethyl-phenyl)-4-hydroxy-5-(tetrahydro-thiopyran-4-ylmethyl)-1,5-dihydro-pyrrol-2-one (compound P2.5) (1.0 g, 3.15 mmol), potassium carbonate (0.87 g, 6.3 mmol) and benzyl bromide (0.81 g, 4.7 mmol) in 10 ml of acetone was refluxed for 2 h. Then, the reaction mixture was filtered and the filtrate was concentrated under vacuum. The residue was purified by chromatography on silica gel. Yield: 640 mg of 4-benzyloxy-3-(2,5-dimethyl-phenyl)-5-(tetrahydro-thiopyran-4-ylmethyl)-1,5-dihydro-pyrrol-2-one as a solid.

Provenance & Evidence