Cyanamide → HCID 88949240, compound

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Reaction Steps

A mixture of carbonic acid 4-(2,5-dimethyl-phenyl)-5-oxo-2-(tetrahydro-thiopyran-4-ylmethyl)-2,5-dihydro-1H-pyrrol-3-yl ester ethyl ester (compound P1.2) (184 mg, 0.47 mmol), NH2CN (40 mg, 0.95 mmol), (diacetoxyiodo)benzene (247 mg, 0.76 mmol), MgO (75 mg, 1.87 mmol) and rhodium acetate (10 mg, 0.02 mmol) in 10 ml of CH2Cl2 was stirred at room temperature for 2 h. Then, the mixture was filtered and the filtrate was concentrated under vacuum. The residue was purified by chromatography on silica gel. Yield: 110 mg of carbonic acid 2-(1-cyanoimino-hexahydro-1λ4-thiopyran-4-ylmethyl)-4-(2,5-dimethyl-phenyl)-5-oxo-2,5-dihydro-1H-pyrrol-3-yl ester ethyl ester (title compound P1.9) as a solid, mp 103-105° C.

Provenance & Evidence