Hydrochloric Acid → HCID 86707845, compound

Participants

Reaction Steps

Concentrated hydrochloric acid (7 mL) was added to a solution of 1-methoxy-4-methoxymethylene-piperidine (9.2 g, 58 mmol) in THF (100 mL), and the mixture was stirred at room temperature for 4 h. The organic solvent was removed under reduced pressure, and the reaction mixture was partitioned between methylene chloride and water. The separated organic layer was dried over sodium sulfate, filtered and concentrated in vacuum. The crude product was purified by column chromatography on silica gel. Yield: 7.5 g of 1-methoxy-piperidine-4-carbaldehyde as an oil.

Provenance & Evidence