Water → HCID 68299252, compound

Participants

Reaction Steps

To a stirred mixture of amino-(1-methoxy-piperidin-4-yl)-acetonitrile (500 mg, 2.95 mmol) and Et3N (610 mg, 6.02 mmol) in THF (15 ml), was added (2,4,6-trimethyl-phenyl)-acetyl chloride (581 mg, 2.95 mmol). After the addition, the mixture was stirred at room temperature for 0.5 h. Then, the mixture was poured into water (100 ml) and extracted with CH2Cl2 (3×50 ml). The combined organic layers were dried over Na2SO4, filtered and evaporated under vacuum. The residue was purified by chromatography on silica gel. Yield: 700 mg of N-[cyano-(1-methoxy-piperidin-4-yl)-methyl]-2-(2,4,6-trimethyl-phenyl)-acetamide as a solid.

Provenance & Evidence