Hydrochloric Acid → HCID 68299225, compound

Participants

Reaction Steps

To a solution of (1-methoxy-piperidin-4-yl)-[2-(2,4,6-trimethyl-phenyl)-acetylamino]-acetic acid methyl ester (1.217 g, 3.36 mmol) in DMF (6 ml) at 90° C. under nitrogen was added t-BuOK (1.12 g, 10 mmol), the mixture was stirred for 10 min. Then the reaction mixture was poured into diluted hydrochloric acid and concentrated in vacuum. The crude product was purified by column chromatography on silica gel. Yield: 960 mg of 4-hydroxy-5-(1-methoxy-piperidin-4-yl)-3-(2,4,6-trimethyl-phenyl)-1,5-dihydro-pyrrol-2-one (compound P2.12) as a solid, mp 206-209° C.

Provenance & Evidence