Potassium Cyanide → HCID 86707846, compound

Participants

Reaction Steps

NaHSO3 (11.4 g, 110 mmol) was added to a solution of 1-methoxy-piperidine-4-carbaldehyde (7.5 g, 52.4 mmol) in water (200 mL). After the mixture was stirred at room temperature for 3 h, a solution of KCN (7.2 g, 110 mmol) in water (100 mL) was added to the mixture. The reaction mixture was stirred for 2 h. Then the mixture was extracted with ethyl acetate three times. The combined organic layers were dried over sodium sulfate, concentrated under vacuum to dryness and the residue was purified by column chromatography on silica gel. Yield: 6.2 g of hydroxy-(1-methoxy-piperidin-4-yl)-acetonitrile as an oil.

Provenance & Evidence