Triethylamine → HCID 68299226, compound

Participants

Reaction Steps

(2,4,6-Trimethyl-phenyl)-acetyl chloride (588 mg, 3 mmol) was added slowly to a mixture of hydroxy-(1-methoxy-piperidin-4-yl)-acetonitrile (390 mg, 2.3 mmol) and Et3N (505 mg, 5 mmol) in THF (10 ml) at 0° C. After the addition was completed, the mixture was stirred at room temperature for 16 h. Then, the mixture was concentrated under vacuum to dryness, the residue was purified by column chromatography on silica.

Provenance & Evidence