Chlorosulfonic acid → 1403387-05-2

HRID 1844688Notes

Reaction equation

HRID 1844688 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([O:11][CH3:12])=[O:10])[CH:5]=[CH:6][CH:7]=1.[Cl:13][S:14](O)(=[O:16])=[O:15]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:14]([Cl:13])(=[O:16])=[O:15])=[C:4]([CH2:8][C:9]([O:11][CH3:12])=[O:10])[CH:3]=1

Participants

3

Reactant 2

HCID 24638Chlorosulfonic acidHCID 11746402Methyl 2-(3-bromophenyl)acetate

Product 1

HCID 901507741403387-05-2

Procedure

Methyl 2-(3-bromophenyl)acetate (22 g, 67 mmol) was slowly added into ClSO3H at −10° C. After 1 h, the mixture was warmed up to rt and stirred overnight, diluted slowly with ice water and extracted with EA. The organic layer was washed with water, dried over Na2SO4 and evaporated to give compound P15a (17 g, 54%).

Workup

  1. extractionextracted with EA
  2. washThe organic layer was washed with water
  3. dry with materialdried over Na2SO4
  4. customevaporated
  5. customto give compound P15a (17 g, 54%)

Sources & evidence

ORD record
ord-6bdd0a8009b1423cbe5b959f58aecfca
Source dataset
uspto-grants-2015_02
Patent number
US08946446B2

Reaction notes

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