N-bromobutanimide → 4-bromo-2-tert-butylphenylamine

Participants

Reaction Steps

To a solution of 2-tert-butylaniline (14.9 g, 100 mmol) was added a solution of NBS (17.8 g, 100 mmol) in DMF at rt. The reaction mixture was stirred for 1 h at rt, diluted with water (30 mL) and extracted with Et2O (3×250 mL). The organic layer was washed with brine, dried over Na2SO4, concentrated and purified by CC to give compound P25a (19 g, 83%).

Provenance & Evidence