Hydrochloric Acid → 1-(Cyclohexylmethyl)-N-cyclopropyl-2-methyl-1H-pyrrole-3-sulfonamide

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Reaction Steps

To a solution of compound 3b (6.0 g, 17.6 mmol) in EtOH (100 mL) was added 4N aq. HCl (50 mL) and the solution was refluxed for 5 h, cooled to rt and concentrated. The residue was diluted with EA, washed with brine, dried over Na2SO4, filtered, concentrated and purified by CC (EA/PE=1/5) to give compound 3c (3.2 g, 61%) as a white solid.

Provenance & Evidence