Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | HCID 70869316 | HCID 70869316 | — |
| Reactant | HCID 70874984 | HCID 70874984 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 86719136 | HCID 86719136 | 44.2% |
Reaction Steps
A mixture of bromide 10a (100 mg, 0.22 mmol), boronic ester P19 (106 mg, 0.27 mmol), Cs2CO3 (181 mg, 0.56 mmol) and Pd(dppf)Cl2 (50 mg) in dioxane and water (10:1, 100 mL) was heated at 100° C. overnight. The solvent was removed, diluted with water, extracted with EA (3×), the combined organic layers were washed with brine, dried over Na2SO4 and concentrated to give product 10 (62 mg, 44%) as yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08946446B2 |
|---|
| Source dataset | uspto-grants-2015_02 |
|---|
| ORD ID | ord-9a486e11b70f46f184ef4c4e1616f868 |
|---|
| Source note | uspto-grants-2015_02 |
|---|
