HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1844726Generated: October 31, 2026
Water → 1-Bromo-3-(tert-butyl)-5-methoxybenzene
https://huagongshe.com/reaction/1844726
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1,3-dibromo-5-tert-butylbenzene | HCID 2761170 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-Bromo-3-(tert-butyl)-5-methoxybenzene | HCID 58745549 | 82% |
Reaction Steps
To a solution of 1,3-dibromo-5-tert-butylbenzene (289 mg, 1 mmol) in DMF (20 mL) were added NaOMe (2 eq) and CuI (0.03 eq). The mixture was stirred at 80° C. for 3 h and then was poured into water and extracted with EA. The combined organic layers were washed with brine and dried over Na2SO4. After filtration, the filtrate was evaporated to give compound 14a as solid (200 mg, 82%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08946446B2 |
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| Source dataset | uspto-grants-2015_02 |
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| ORD ID | ord-58ad272b773d4da4bb8db892f13e510c |
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| Source note | uspto-grants-2015_02 |
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