Isobutyl iodide → HCID 70869094, compound

Participants

Reaction Steps

To a solution of compound 17b (1.0 g, 4.33 mmol) in dry DMF (10 mL) was added NaH (0.31 g, 13 mmol) under N2 and the mixture was stirred at rt for 1 h. Then 1-iodo-2-methylpropane (1.35 g, 7.3 mmol) was added and the resulting mixture was heated at 80° C. overnight. The mixture was quenched with water (5 mL) and extracted with EA twice. The combined organic layers were washed with brine (3×), concentrated and purified by CC (PE/EA=50/1) to give compound 17c (1.0 g, 91%) as an oil.

Provenance & Evidence