HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-Bromo-5-(cyclohexylmethyl)-1-methyl-1H-pyrrole-2-sulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 5-(Cyclohexylmethyl)-1-methyl-1H-pyrrole-2-sulfonamide | HCID 70874051 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-Bromo-5-(cyclohexylmethyl)-1-methyl-1H-pyrrole-2-sulfonamide | HCID 86719138 | 103.5% |
Reaction Conditions
| Temperature | -78 °C |
|---|
Reaction Steps
To a solution of NBS (68.7 mg, 386 μmol) was added a solution of compound 25e (104 mg, 410 μmol) in THF at −78° C. and stirred for 2 h at −78° C. Water (30 mL) was added and the reaction mixture was extracted with EA (150 mL). The organic layer was washed with brine, dried over Na2SO4, concentrated and purified by CC (hexane/EA=3/1) to give compound 25f (134 mg, 61%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946446B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-5e4988c72fec42c39b0f3099d8f825d1 |
| Source note | uspto-grants-2015_02 |