Chlorosulfonic acid → 1-[(4-Methylphenyl)sulfonyl]-1H-pyrrole-3-sulfonyl chloride

Participants

Reaction Steps

To a stirred solution of compound 27a (5.0 g, 22.6 mmol) in ACN (50 mL) was carefully added ClSO3H (15.8 g, 136 mmol) and the solution was stirred at rt overnight, poured on ice-water and extracted with CHCl3 twice. The combined organic layers were washed with aq. NaHCO3 and brine (3×), concentrated and purified by CC (PE/EA=50/1) to give compound 27b (1.45 g, 20%) as a solid.

Provenance & Evidence