HCID 70913855, compound → HCID 70913850, compound

Participants

Reaction Steps

To a stirred solution of compound 36 (86 mg, 0.19 mmol) in dry THF (2 mL) was added CH3MgBr (3M, 70 μL, 0.21 mmol) and the mixture was stirred at rt for 2 h, quenched with aq. NH4Cl at 0° C. and extracted with EA. The organic layer was concentrated and purified by CC (PE/EE=4/1) to give compound 37 (21 mg, 24%) as a colorless solid. 1H-NMR (CDCl3+D2O, 400 MHz) δ: 0.67-0.72 (2H, m), 0.88-0.91 (2H, m), 1.01-1.05 (5H, m), 1.36-1.44 (3H, m), 1.60 (9H, m), 1.93-1.95 (2H, t, J=10.4 Hz), 2.52 (3H, s), 3.63-3.65 (2H, d, J=7.2 Hz), 4.43-4.45 (2H, t, J=10.4 Hz), 6.35 (1H, s), 6.49 (1H, s), 6.98 (1H, s). MS Calcd.: 472; MS Found: 473 (M+1)+.

Provenance & Evidence