Water → HCID 70874528, compound

Participants

Reaction Steps

To a solution of compound 1 (1.0 g, 2.25 mmol) in dry DMF (10 mL) was added NaH (60%, 92 mg, 2.3 mmol) at 0° C. and the mixture was stirred for 10 min, ethyl 3-bromopropanoate (410 mg, 2.25 mmol) was added and stirred at rt for 5 h. Water was added and the solution was extracted with EA. The organic layer was washed with brine twice, concentrated and purified by CC (PE/EA=5/1) to give compound 38 (400 mg, 34%) as a white solid.

Provenance & Evidence