Lithium hydroxide, monohydrate → HCID 70874583, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of compound 38 (400 mg, 0.75 mmol) in a mixture of MeOH (10 mL) and water (3 mL) was added LiOH.H2O (200 mg, 4.60 mmol) and then this mixture was stirred at 60° C. for 4 h, evaporated and acidified to pH˜5 with 3N HCl. The aq. layer was extracted with EA (3×). The combined organic layers were concentrated and purified by CC (PE/EA=2/1) to give compound 39 (345 mg, 79%) as a colorless oil. 1H-NMR (CDCl3, 300 MHz) δ: 0.60-0.66 (2H, m), 0.93-1.02 (3H, m), 1.23-1.38 (3H, m), 1.34 (18H, s), 1.51-1.55 (3H, m), 2.51 (3H, s), 2.64 (2H, t, J=5.4 Hz), 3.23-3.29 (2H, m), 3.70 (2H, d, J=7.2 Hz), 5.45 (1H, m), 6.42 (1H, s), 7.14 (2H, s), 7.40 (1H, s). MS Calcd.: 516; MS Found: 517 (M+1).

Provenance & Evidence