HCID 70913732, compound → HCID 70913730, compound

Participants

Reaction Steps

To a solution of compound 47 (330 mg, 0.70 mol) in dry THF (5 mL) was added a solution of BH3 in THF (1M, 7 mL, 7 mmol) dropwise under cooling with an ice-bath. After the addition, the mixture was stirred at rt overnight, slowly diluted MeOH (5 mL), concentrated and purified by CC (DCM/MeOH=10/1) to give compound 48 (280 mg, 87%) as a white solid. 1H-NMR (DMSO-d6, 400 MHz) δ: 0.64-0.67 (2H, m), 0.89-0.96 (3H, m), 1.21-1.35 (20H, m), 1.46 (3H, d, J=8.0 Hz), 2.44 (3H, s), 3.03 (2H, s), 3.78 (3H, d, J=6.8 Hz), 6.31 (1H, s), 6.93 (2H, s), 7.18 (1H, s), 7.24 (1H, s), 7.37 (1H, s). MS Calcd.: 459; MS Found: 460, (M+1).

Provenance & Evidence