Acetic Anhydride → HCID 70913733, compound

Participants

Reaction Steps

To a solution of compound 48 (100 mg, 0.22 mmol) in dry DCM (5 mL) was added Ac2O (25 mg, 0.24 mmol) at 0° C. and then the solution was stirred overnight at rt, concentrated and purified by prep-TLC to afford compound 49 (60 mg, 54%) as a white solid. 1H-NMR (DMSO-d6, 400 MHz) δ: 0.64-0.67 (2H, m), 0.93-0.95 (3H, m), 1.26-1.30 (20H, m), 1.46 (3H, d, J=6.8 Hz), 1.77 (3H, s), 2.43 (3H, s), 3.28 (2H, d, J=5.6 Hz), 3.76 (3H, d, J=7.2 Hz), 6.28 (1H, s), 6.91 (2H, s), 7.09 (1H, s), 7.16 (1H, s), 7.35 (1H, s), 7.67 (1H, m). MS Calcd.: 501; MS Found: 502 (M+1).

Provenance & Evidence