HCID 86719142, compound → HCID 70913502, compound

Participants

Reaction Steps

Crude intermediate 52 (0.50 mmol) was dissolved in dry MeOH/HCl under N2. The mixture was stirred overnight at rt, concentrated, treated with 3% aq. K2CO3, extracted with DCM, dried over Na2SO4, filtered, concentrated and purified by prep-HPLC to afford compound 53 (95 mg, 35%). 1H-NMR (DMSO-d6, 400 MHz) δ: 0.50-0.62 (2H, m), 0.83-0.95 (3H, m), 1.13-1.39 (3H, m), 1.41-1.50 (3H, m), 2.47 (3H, s), 3.81 (2H, d, J=5.6 Hz), 6.47 (1H, s), 7.00 (2H, s), 7.30-7.39 (2H, m), 7.50-7.54 (1H, m), 7.68-7.80 (4H, m), 8.00 (1H, s), 8.38-8.42 (1H, m). MS Calcd.: 545; MS Found: 546 (M+1).

Provenance & Evidence