Hydrochloric Acid → HCID 57331533, compound

Participants

Reaction Steps

0.75 g (2.74 mmol) (4-ethynyl-3-nitrophenyl) (4-methylpiperazin-1-yl)ketone (Compound I-24) and 7.5 ml anhydrous methanol were added into a 50 ml single-neck flask, magnetically stirred to dissolve. The mixture was adjusted to a pH value of 2 by adding concentrated hydrochloric acid. A white solid was precipitated under cooling with ice water, and filtered. The filter cake was washed with anhydrous ethanol, dried to obtain 0.46 g (4-ethynyl-3-nitrophenyl) (4-methylpiperazin-1-yl)ketone hydrochloride (Compound I-29), yield: 54.1%.

Provenance & Evidence