Methanol → HCID 56849102, compound

Participants

Reaction Steps

In a dried reaction flask, methyl 2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinoline-7-carboxylate (0.868 g, 2.0 mmol) and 10% aqueous NaOH solution (2.4 mL, 6.0 mmol) were dissolved into a mixture of methanol (4 mL) and tetrahydrofuran (10 mL). The reaction solution was stirred at room temperature for 15 hr. The solution was concentrated at a reduced pressure to reduce half of the volume. The residue was adjusted with 1 M HCl under an ice bath to a pH value of 2-3, and filtered to obtain a crude yellow solid, which was then washed with ethanol and ethyl ether to obtain a solid (0.496 g) in 59.0% yield.

Provenance & Evidence