HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine, hydrochloride → HCID 56849103, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine, hydrochloride | HCID 10473 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 56849102 | HCID 56849102 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 56849103 | HCID 56849103 | — |
Reaction Steps
In a dried reaction flask, the crude 2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinoline-7-carboxylic acid (Compound 1) (0.4 g, about 0.9 mmol), dimethylamine hydrochloride (0.095 g, 1.17 mmol), DIEA (N,N-diisopropylethylamine, the same below) (0.18 mL, 1.04 mmol) and HATU (2-(7-azobenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate, the same below) (0.342 g, 0.899 mmol) were added to a mixed solvent of DMF (dimethylformamide) (6.5 mL) and dichloromethane (6.5 mL). The mixture was stirred at room temperature for 3 hr and water was added.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946279B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-af48eccde9454a65b9173c64e9a3e6d8 |
| Source note | uspto-grants-2015_02 |