Formaldehyde → HCID 86700927, compound

Participants

Reaction Steps

To a dried 100 mL single-mouth round bottom flask were added absolute methanol (40 mL), and then the starting materials (S)-butyl 3-aminopyrrolidine-1-carboxylate (1.86 g, 10 mmol), paraformaldehyde (3 g), anhydrous magnesium sulfate (2.5 g), acetic acid (1.2 g) and sodium cyanoborohydride (2.5 g, 39.8 mmol). The mixture was stirred at room temperature for 24 hr. The reaction system was poured into water to quench, concentrated under reduced pressure. The residue was extracted with ethyl acetate, the combined organic layer was concentrated under reduced pressure to obtain a crude yellow viscous product (4.0 g).

Provenance & Evidence