Sodium hydride → HCID 58409938, compound

Participants

Reaction Steps

A mixture of 6-(4-fluorophenyl)-2-oxo-4-(piperidin-1-yl)-2H-pyran-3-carbonitrile (298 mg), indanone-1 (132 mg) and NaH (36 mg) in THF was stirred for <5 min. After completion, the reaction solvent was evaporated under vacuum to dryness and crude solid was quenched with ice water and subsequently neutralized with dil. HCl, finally purified by column chromatography using ethylacetate-hexane as eluent. Yellow solid; mp 176-178° C.; FAB MS 368 (M+); IR (KBr) 2220 cm−1 (CN); HRMS calcd. for C25H21FN2 368.16888. Found 368.16806.

Provenance & Evidence