Tetrahydrofuran → HCID 58409936, compound

Participants

Reaction Steps

A mixture of 2-oxo-6-phenyl-4-(piperidin-1-yl)-2H-pyran-3-carbonitrile (280 mg), indanone-2 (132 mg) and NaH (44 mg) in THF was stirred for <5 min. After completion, the reaction solvent was evaporated under vacuum to dryness and crude solid was quenched with ice water and subsequently neutralized with dil. HCl, finally purified by column chromatography using ethylacetate-hexane as eluent. White solid; mp 140-141° C.; ESIMS 351 (M++1); IR (KBr) 2219 cm−1 (CN); 13C NMR (75.53 MHz, CDCl3): δ 22.89, 24.96, 36.00, 52.15, 100.45, 116.08, 117.93, 120.78, 123.54, 125.06, 125.34, 126.97, 127.35, 127.42, 131.32, 138.85, 139.20, 140.94, 141.01, 149.06, 153.62.

Provenance & Evidence