Sodium hydride → HCID 58409940, compound

Participants

Reaction Steps

A mixture of 6-(naphthalen-1-yl)-2-oxo-4-(piperidin-1-yl)-2H-pyran-3-carbonitrile (330 mg), indanone-2 (132 mg) and NaH (41 mg) in THF was stirred for <5 min. After completion, the reaction solvent was evaporated under vacuum to dryness and crude solid was quenched with ice water and subsequently neutralized with dil. HCl, finally purified by column chromatography using ethylacetate-hexane as eluent. White solid; mp 148-149° C.; ESIMS 401 (M+1); IR (KBr) 2213 cm−1 (CN); 13C NMR (75.53 MHz, CDCl3): δ 22.84, 24.94, 36.08, 52.16, 100.72, 116.12, 118.56, 120.75, 123.36, 124.30, 124.48, 124.92, 125.0, 125.36, 125.43, 127.09, 127.29, 130.15, 132.29, 132.64, 136.40, 138.86, 138.99, 140.82, 148.79, 153.65.

Provenance & Evidence