Tetrahydrofuran → HCID 58409939, compound

Participants

Reaction Steps

A mixture of 2-oxo-4-(piperidin-1-yl)-6-p-tolyl-2H-pyran-3-carbonitrile (294 mg), indanone-2, (132 mg) and NaH (29 mg) in THF was stirred for <5 min. After completion, the reaction solvent was evaporated under vacuum to dryness and crude solid was quenched with ice water and subsequently neutralized with dil. HCl, finally purified by column chromatography using ethylacetate-hexane as eluent. White solid; mp 162-164° C.; ESMS 365 (M++1); IR (KBr) 2213 cm−1 (CN); HRMS calcd. for C26H24N2 364.1940 found 364.1936.

Provenance & Evidence