Sodium hydride → HCID 58409932, compound

Participants

Reaction Steps

A mixture of 2-oxo-4-(piperidin-1-yl)-2,5-dihydroindeno[1,2-b]pyran-3-carbonitrile (292 mg), indanone-1 (132 mg) and NaH (41 mg) in THF was stirred for <5 min. After completion, the reaction solvent was evaporated under vacuum to dryness and crude solid was quenched with ice water and subsequently neutralized with dil. HCl, finally purified by column chromatography using ethylacetate-hexane as eluent. White solid; mp 186-188° C.; 1H NMR (200 MHz, CDCl3) δ 1.66-1.70 (m, 2H, CH2), 1.81-1.85 (m, 2H, CH2), 3.34-3.42 (m, 4H, CH2), 4.11 (s, 2H, CH2), 4.17 (s, 2H, CH2), 7.40-7.46 (m, 4H, ArH), 7.60-7.68 (m, 2H, ArH), 7.92 (d, 1H, J=7.8 Hz, ArH), 8.52 (d, 1H, J=7.5 Hz, ArH); MS (ESI) 363 (M+1).

Provenance & Evidence