Tetrahydrofuran → HCID 58409951, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 4-(naphthalen-1-yl)-2-(piperidin-1-yl)-9H-fluorene-1-carbonitrile (400 mg) in THF was added sodium hydride (37 mg) and was stirred at 0-5° C. for less than five minutes. After completion, the reaction solvent was evaporated under vacuum and the crude solid obtained was quenched with ice water and subsequently neutralized by dilute HCL. The precipitate thus obtained was filtered and purified on a silica gel column using ethyl acetate-hexane as eluent. Light red solid; mp 202-204° C.; ESIMS 0.415 (M++1); IR (KBr) 2221 (CN), 1719 cm−1 (CO), HRMS calcd. for C29H22N2O 414.1732. Found 414.1714.

Provenance & Evidence