反应详情

A mixture of 2-chloro-4-iodopyridine (6.43 g, 26.3 mmol), (4-cyclopentylphenyl)boronic acid (5.0 g, 26.3 mmol), Pd(Ph3P)4 (0.0.91 g 0.79 mmol), sodium carbonate (8.37 g, 79 mmol), DME (257 mL) and water (64 mL) was degassed with nitrogen and then refluxed overnight. The reaction mixture was concentrated and extracted with ethyl acetate. The the ethyl acetate layer was dried on Na2SO4 and then further purified by column chromatography using dichloromethane in hexanes and then vacuum distilled to give 2-Chloro-4-(4-cyclopentylphenyl)pyridine (4.6 g, 68% yield).

1. customwas degassed with nitrogen
2. temperaturerefluxed overnight
3. concentrationThe reaction mixture was concentrated
4. extractionextracted with ethyl acetate
5. dry with materialThe the ethyl acetate layer was dried on Na2SO4
6. customfurther purified by column chromatography
7. distillationvacuum distilled