反应详情

A mixture of 2-chloro-4-iodopyridine (10.0 g, 41.8 mmol), p-tolylphenylboronic acid (5.68 g, 41.8 mmol), Pd(Ph3P)4 (1.45 g 1.25 mmol), sodium carbonate (13.3 g, 125 mmol), DME (300 mL) and water (75 mL) was degassed with nitrogen and then refluxed overnight. The reaction mixture was concentrated and extracted with ethyl acetate. The ethyl acetate layer was dried on Na2SO4 and vacuum distilled and recrystallized to give 2-chloro-4-(p-tolyl)pyridine (3.75 g, 18.4 mmol, 44% yield).

1. customwas degassed with nitrogen
2. temperaturerefluxed overnight
3. concentrationThe reaction mixture was concentrated
4. extractionextracted with ethyl acetate
5. dry with materialThe ethyl acetate layer was dried on Na2SO4 and vacuum
6. distillationdistilled
7. customrecrystallized